GJB2 Gene Mutations in Cochlear Implant Recipients

GJB2 gene mutations in cochlear implant recipients: prevalence and impact on outcome.

OBJECTIVE To determine the prevalence of GJB2 gene mutations in patients undergoing cochlear implantation (CI) and their impact on rehabilitative outcome following implantation. DESIGN Prospective determination of GJB2 mutation by sequence analysis by denaturing high-performance liquid chromatography and its correlation with outcome following CI. SETTINGS Two tertiary academic medical cente...

Long-Term Cochlear Implant Outcomes in Children with GJB2 and SLC26A4 Mutations

OBJECTIVES To investigate speech and language outcomes in children with cochlear implants (CIs) who had mutations in common deafness genes and to compare their performances with those without mutations. STUDY DESIGN Prospective study. METHODS Patients who received CIs before 18 years of age and had used CIs for more than 3 years were enrolled in this study. All patients underwent mutation s...

Radiation therapy in cochlear implant recipients.

HYPOTHESIS Processes of scattering and attenuation were investigated to determine the consequence on dose distributions by having a cochlear implant in the field of therapeutic radiation. BACKGROUND Radiation oncology medical accelerator beams of 6- and 18-MV x-ray energy were used. Five cochlear implants were investigated. METHODS Each implant model was individually studied using computer ...

Cochlear implant recipients at risk for meningitis.

The Cochlear Implant

The studies on cochlear implants have been conducted in the United States, Austria, Brasil, France, Finland, and some other countries. Up to now, this technique does not seem to have a wide spread application. Indeed it can only apply cases of deafness still presenting sufficient neural remnants to transmit the message. Moreover, the patient must be totally deaf( quasi­ complete loss of har cel...